{"id":603,"date":"2017-06-09T16:40:34","date_gmt":"2017-06-09T19:40:34","guid":{"rendered":"https:\/\/investigacaoemdermatologia.com.br\/new\/?p=603"},"modified":"2017-06-13T18:31:35","modified_gmt":"2017-06-13T21:31:35","slug":"paradoxical-psoriasis-after-the-use-of-anti-tnf-in-patient-with-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/investigacaoemdermatologia.com.br\/?p=603","title":{"rendered":"Paradoxical psoriasis after the use of anti-TNF in a patient with rheumatoid arthritis."},"content":{"rendered":"<p><strong>Autores:<\/strong>\u00a0Vasconcellos JB1, Pereira DD1, Vargas TJ2, Levy RA1, Pinheiro GD1, Cursi \u00cdB1.<\/p>\n<p><span class=\"m_7201728824284618788gmail-highlight\"><strong>Abstract:<\/strong> The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of infliximab for rheumatoid arthritis, developed psoriasis. In an attempt to switch anti-TNF class, we observed a cumulative worsening of the lesions requiring suspension of the immunobiological agent and the introduction of other drugs for clinical control. The therapeutic challenge of this paradoxical form of psoriasis is the focus of our discussion. The use of another anti-TNF in these patients is a matter of debate among experts.<\/span><\/p>\n<a href=\"https:\/\/investigacaoemdermatologia.com.br\" class=\"su-button su-button-style-flat\" style=\"color:#FFFFFF;background-color:#AB2941;border-color:#892134;border-radius:5px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#FFFFFF;padding:0px 16px;font-size:13px;line-height:26px;border-color:#c56a7a;border-radius:5px;text-shadow:none\"> Veja a publica\u00e7\u00e3o<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"<p>Autores:\u00a0Vasconcellos JB1, Pereira DD1, Vargas TJ2, Levy RA1, Pinheiro GD1, Cursi \u00cdB1. Abstract: The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during &hellip; <a href=\"https:\/\/investigacaoemdermatologia.com.br\/?p=603\" class=\"more-link\">Continue lendo <i class=\"fa fa-arrow-circle-o-right\"><\/i><\/a><\/p>\n","protected":false},"author":5,"featured_media":617,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicacoes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Paradoxical psoriasis after the use of anti-TNF in a patient with rheumatoid arthritis. - Investiga\u00e7\u00e3o em Dermatologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/investigacaoemdermatologia.com.br\/?p=603\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joaquim Jeunon\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603\"},\"author\":{\"name\":\"Joaquim Jeunon\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/#\\\/schema\\\/person\\\/55987b91349c9a519430fca2aa358f1b\"},\"headline\":\"Paradoxical psoriasis after the use of anti-TNF in a patient with rheumatoid arthritis.\",\"datePublished\":\"2017-06-09T19:40:34+00:00\",\"dateModified\":\"2017-06-13T21:31:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603\"},\"wordCount\":160,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/wp-content\\\/uploads\\\/2017\\\/06\\\/Capa-rev-ABD-Vol-91Supl1_vertical.png\",\"articleSection\":[\"Publica\u00e7\u00f5es\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603\",\"url\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=603\",\"name\":\"Paradoxical psoriasis after the use of anti-TNF in a patient with rheumatoid arthritis. - 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