{"id":162,"date":"2015-12-16T13:19:25","date_gmt":"2015-12-16T16:19:25","guid":{"rendered":"https:\/\/investigacaoemdermatologia.com.br\/new\/?p=162"},"modified":"2016-01-11T14:30:14","modified_gmt":"2016-01-11T17:30:14","slug":"adult-t-cell-leukemialymphoma-a-case-report-of-primary-cutaneous-tumoral-dermatology-practical-and-conceptual","status":"publish","type":"post","link":"https:\/\/investigacaoemdermatologia.com.br\/?p=162","title":{"rendered":"Adult T-cell leukemia\/lymphoma: a case report of primary cutaneous tumoral &#8211; Dermatology Practical &#038; Conceptual Journal"},"content":{"rendered":"<p>A 38-year-old woman presented some ellipsoid scaling patches lasting 18 months and developed a large tumoral lesion in the abdomen, which were previously diagnosed as MF. Although histopathologic and immunohistochemistry findings were in consonance with this diagnosis, the fast progression of the disease raised the suspicion that it could represent another type of T-cell lymphoma. The work-up revealed a positive anti-HTLV-1 serology and molecular studies confirmed the monoclonal integration of HTLV-1 provirus into neoplastic cells of the skin, but not into circulating lymphocytes. Extensive investigations were unable to demonstrate any systemic involvement. The final diagnosis was of primary cutaneous type of ATLL. The patient was submitted to a chemotherapy regimen with cyclophosphamide, doxorubicin, vincristine and prednisone, later to conjugated dexamethasone and surgical cytoreduction and then to a second line treatment with gemcitabine, resulting in partial response. A bone marrow heterologous transplantation was performed, but failed to achieve a sustained remission.<\/p>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3663345\/\" class=\"su-button su-button-style-flat\" style=\"color:#FFFFFF;background-color:#AB2941;border-color:#892134;border-radius:5px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#FFFFFF;padding:0px 16px;font-size:13px;line-height:26px;border-color:#c56a7a;border-radius:5px;text-shadow:none\"> Veja a publica\u00e7\u00e3o<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"<p>A 38-year-old woman presented some ellipsoid scaling patches lasting 18 months and developed a large tumoral lesion in the abdomen, which were previously diagnosed as MF. Although histopathologic and immunohistochemistry findings were in consonance with this diagnosis, the fast progression of the disease raised the suspicion that it could represent another type of T-cell lymphoma. &hellip; <a href=\"https:\/\/investigacaoemdermatologia.com.br\/?p=162\" class=\"more-link\">Continue lendo <i class=\"fa fa-arrow-circle-o-right\"><\/i><\/a><\/p>\n","protected":false},"author":5,"featured_media":349,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicacoes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Adult T-cell leukemia\/lymphoma: a case report of primary cutaneous tumoral - Dermatology Practical &amp; Conceptual Journal - Investiga\u00e7\u00e3o em Dermatologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/investigacaoemdermatologia.com.br\/?p=162\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joaquim Jeunon\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=162#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=162\"},\"author\":{\"name\":\"Joaquim Jeunon\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/#\\\/schema\\\/person\\\/55987b91349c9a519430fca2aa358f1b\"},\"headline\":\"Adult T-cell leukemia\\\/lymphoma: a case report of primary cutaneous tumoral &#8211; 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