{"id":159,"date":"2015-12-16T10:53:22","date_gmt":"2015-12-16T13:53:22","guid":{"rendered":"https:\/\/investigacaoemdermatologia.com.br\/new\/?p=159"},"modified":"2016-01-11T14:30:10","modified_gmt":"2016-01-11T17:30:10","slug":"langerhans-cell-histiocytosisa-case-report-dermatology-practical-and-conceptual","status":"publish","type":"post","link":"https:\/\/investigacaoemdermatologia.com.br\/?p=159","title":{"rendered":"Langerhans cell histiocytosis?a case report – Dermatology Practical & Conceptual Journal"},"content":{"rendered":"

A 17-year-old male presented for dermatologic consultation with slightly elevated reddish papules covered by yellowish scales in the scalp for the last two years and reddish and indurated ulcers in the perineum lasting six months. Additional complaints included polyuria, polydipsia, delay in the development of secondary sexual characteristics and hearing loss of the right ear secondary to a medium otitis. Lesions from scalp and perineum were sampled for histopathologic examination and revealed a dense cellular infiltrate made up of mononuclear cells with conspicuous eosinophilic cytoplasm and large cleaved vesicular nucleus, some of them with shapes resembling the format of a kidney and others reminiscent of coffee beans. Numerous intermingling eosinophils were present. The diagnosis of Langerhans cell histiocytosis was then rendered and confirmed by positive immunostaining of neo-plastic cells for anti-CD1a and anti-S100 protein antibodies. The work-up revealed diabetes insipidus, hypogonadotropic hypogonadism, hiperprolactenemia, growing-hormone deficiency and thickness of the pituitary stalk. The patient was treated with prednisone and vinblastin based chemotherapy regimen for six months with complete remission, but presented recurrence of some lesions in the scalp, which were handled with topical mustard and corticosteroids. After chemotherapy, the endocrinologic disturbances were corrected with hormonal replacement therapy. The patient is currently in good health with a follow-up of five years.<\/p>\n Veja a publica\u00e7\u00e3o<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"

A 17-year-old male presented for dermatologic consultation with slightly elevated reddish papules covered by yellowish scales in the scalp for the last two years and reddish and indurated ulcers in the perineum lasting six months. Additional complaints included polyuria, polydipsia, delay in the development of secondary sexual characteristics and hearing loss of the right ear … Continue lendo <\/i><\/a><\/p>\n","protected":false},"author":5,"featured_media":349,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-159","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicacoes"],"yoast_head":"\nLangerhans cell histiocytosis?a case report - Dermatology Practical & Conceptual Journal - Investiga\u00e7\u00e3o em Dermatologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/investigacaoemdermatologia.com.br\/?p=159\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joaquim Jeunon\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159\"},\"author\":{\"name\":\"Joaquim Jeunon\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/#\\\/schema\\\/person\\\/55987b91349c9a519430fca2aa358f1b\"},\"headline\":\"Langerhans cell histiocytosis?a case report – Dermatology Practical & Conceptual Journal\",\"datePublished\":\"2015-12-16T13:53:22+00:00\",\"dateModified\":\"2016-01-11T17:30:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159\"},\"wordCount\":245,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/wp-content\\\/uploads\\\/2015\\\/12\\\/dpc-journal.png\",\"articleSection\":[\"Publica\u00e7\u00f5es\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159\",\"url\":\"https:\\\/\\\/investigacaoemdermatologia.com.br\\\/?p=159\",\"name\":\"Langerhans cell histiocytosis?a case report - 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